Yes Rachael Boles you don't have to necessarily take much either. Cymbalta and Lidocaine patches were the only things that gave me relief from the living hell of seven whole years of CRPS pain, which I suffered along with the severe brain fog (a known neuro symptom). After 10 months of not being able to walk while bone spur developed in the other foot from using crutches, of watching my legs waste away, of most doctors not taking my pain seriously and not listening to me...Well it all finally started getting to me and I couldn't take it any more. I quit P.T. b/c I couldn't take the pain it caused (Later found out they were making a mistake by using ice, which made the CRPS much worse). I also got fed up and crawled around the house one day to get the materials and made my own cardboard and duct-tape foot 'orthotic' (they wouldn't listen to me about that). Then I started joking about shooting my foot off while also reassuring them I wasn't going to do it, but I was willing to get rid of my foot if that's what it took to stop the pain. Eyes got wide then. I had no idea it was a sign of being close to suicide. At the the time, the stats were 30% of CRPS pain disorder kill themselves. So my brain fog was so bad, I didn't even realize my next doctor (whom I was quickly referred to), spoke with me very carefully b/c he was afraid I'd commit suicide next. He ordered the stubborn podiatrists to get me those shoe orthotics. I was right about that all along, and they helped and I could walk for short periods.
Eventually, we bought a puppy which encouraged me to walk outside and stand on my wasted away legs. I needed something to look forward to each day. I still didn't have Cymbalta at this point. But at least I didn't have to fight for doctors not to treat me with cruelty and indifference. It was another six years of hell before Cymbalta. I was the one who asked for an SRNI, b/c I found a neurologist's website that an SRNI (Serotonin and norepinephrine reuptake inhibitor) might help nerve pain whereas the SSRIs usually didn't help (there's a difference). The doctor said Cymbalta was the best option. So after all that time, it took less than 10 mg of Cymbalta (I experimented with filling gelatin capsules b/c I did not want to hit my brain with too much), to start to be able to think again, to have the pain lessen enough to be bearable. This was about a decade ago. We had no idea we had EDS Hypermobility then.
Anyhow, ironically, it was b/c of Cymbalta, which allowed me to think and function better, that I eventually started discovering other solutions for both me and my daughters. I could also remember to do what I needed to do for my own self-treatments (Yes, my brain was once that bad).
My Fibro. daughter would not take meds for several years either. I think in part b/c of my bad experiences with the med Lyrica. She had been through a whole lot including surgeries etc. too, and her brain fog became severe too, along with the Fibro. The L-tryptophan was the key for her. Just like me, the PMS phase of the menstrual cycle caused not just cramps, but more all over pain, from whatever part of your body is in pain. There's one of your clues it could be a dip in serotonin. The depression and anxiety attacks too. L-tryptophan and a little B-6 (as co-factor. Not a lot needed) brought my daughter back from the brink, just like Cymbalta was one of the things that brought me back from the brink.
p.s. To be fair, after another year of improvement yet still too symptomatic, my severe EDS Fibro. daughter tried 5 mg of Cymbalta daily. This was after she could think well enough on the L-tryptophan, noticed the HUGE difference, and I was able to explain to her some of her pain was neuro pain. A doctor supported that assessment. The anxiety attacks stopped with this very small amt. of Cymbalta, as well as another layer of pain. She shouldn't be doing this well on so little medical intervention. Her geneticist expects complete disability, yet she stopped being near bedridden and continues to do better. It's b/c of the D-Ribose, the Mg, the D3, some zinc, the L-tryptophan, of course the Culterelle and other probiotics--now the George's aloe for the past several months. It takes awhile to get better and figure out what works, and give the body and brain time to heal.